A Dual-Functional Ferroferric Oxide/Quantum Dots Theranostic Nanoplatform for Fluorescent Labeling and Photothermal Therapy,Particle & Particle Systems Characterization

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A Dual-Functional Ferroferric Oxide/Quantum Dots Theranostic Nanoplatform for Fluorescent Labeling and Photothermal Therapy
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2021-04-30 , DOI: 10.1002/ppsc.202100043
Naiqiang Yin _{1,

2} , Peng Li ₁ , Xiaoliang Xu ₂ , Lixin Zhu ₃

Affiliation

A biocompatible, nontoxic theranostic nanoplatform consisting of mesoporous silica-coated ferroferric oxide (Fe₃O₄) and Mn-doped ZnS-ZnS quantum dots (QDs) is synthesized via a layer-by-layer method. Transmission electron microscopy, X-ray diffractometer, magnetometry, and fluorophotometer are employed to characterize the nanoplatform. The nanoplatform exhibits excellent superparamagnetic, fluorescent, and light absorption properties. The template method is introduced to form a mesoporous silica structure on the nanoplatform, lowering the mass of the nanoplatform and effectively promoting the absorption efficiency of the incident light compared with the traditional silica layer. In addition, after endocytosis of the nanoplatform, cancer cells are easily detected under a fluorescence microscope because of the excellent fluorescent behavior of QDs. Moreover, in vitro experiments confirm that nanoplatform possesses perfect photothermal effect to destroy tumor cells under laser irradiation. Therefore, ferroferric oxide/QDs nanoplatforms, combined with the functions of fluorescent labeling and photothermal therapy for cancer cells, are expected to be a promising biopotential material in the field of diagnosis and treatment.

中文翻译：

用于荧光标记和光热治疗的双功能氧化铁/量子点治疗诊断纳米平台

一种生物相容性、无毒的诊疗纳米平台，由介孔二氧化硅包覆的三氧化二铁（Fe ₃ O ₄) 和 Mn 掺杂的 ZnS-ZnS 量子点 (QD) 是通过逐层方法合成的。透射电子显微镜、X 射线衍射仪、磁力计和荧光光度计用于表征纳米平台。该纳米平台表现出优异的超顺磁性、荧光和光吸收特性。引入模板法在纳米平台上形成介孔二氧化硅结构，与传统二氧化硅层相比，降低了纳米平台的质量，有效提高了入射光的吸收效率。此外，在纳米平台内吞后，由于量子点的优异荧光行为，在荧光显微镜下很容易检测到癌细胞。而且，体外实验证实，纳米平台具有完美的光热效应，可在激光照射下破坏肿瘤细胞。因此，四氧化三铁/量子点纳米平台结合荧光标记和光热治疗癌细胞的功能，有望成为诊断和治疗领域有前景的生物潜能材料。

更新日期：2021-06-20

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