The object of the present study is to evaluate the effect of alcoholic extracts of Cissus quadrangularis (CQ), Cryptolepis buchanani (CB), and Sardinella longiceps (SL) either alone or in the combination (100 mg/kg) in the management of femur bone healing of Wistar albino rats for 8 weeks. After the period of treatment, femur bones were examined by using biochemical, radiographical, and histopathological studies. Biochemical evaluation results reveal that there is a steep increase of serum calcium level in the experimental animals during the entire period of treatment which led to an adequate supply of serum calcium to the fractured bone for healing and increases the thickness of the femur bones soon compared to control group. It had been estimated by a calibrated ocular micrometer. Radiographical images of the bones also disclose that the complete bridging of fractured bone occurred in the experimental animals after the treatment of natural compound extracts. In addition to that, all the organs of animals were safe in the experimental animals during the entire study. The present study strongly recommended that these ethanolic extracts (CQCBSL) either alone or in the combination restoring the strength of the bone and reduced bone repairing period due to the rich content of calcium and other natural phytochemicals presents with them.

中文翻译：

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评价四角形犬（Linn），布氏隐孢子虫和长沙迪氏菌在Wistar大鼠中的骨愈合活性

本研究的目的是评估四边形犬（CQ），布氏隐孢子虫（CB）和长沙丁鱼（SL）的酒精性提取物单独或组合使用（100 mg / kg）对股骨的治疗作用Wistar白化病大鼠的骨骼愈合8周。治疗期过后，通过生化，射线照相和组织病理学检查检查股骨。生化评估结果表明，在整个治疗过程中，实验动物的血清钙水平急剧上升，这导致与骨折的骨骼相比，有足够的血清钙供应给骨折的骨，以使其愈合，并且与之相比很快增加了股骨的厚度。控制组。它是通过校准的测微计估算的。骨骼的射线照相图像还显示，在天然化合物提取物处理后，实验动物中发生了骨折骨的完全桥接。除此之外，在整个研究过程中，动物的所有器官在实验动物中都是安全的。本研究强烈建议这些乙醇提取物（CQCBSL）单独使用或组合使用，可恢复骨骼的强度并缩短骨骼修复时间，因为它们含有丰富的钙和其他天然植物化学成分。