Chronic kidney disease (CKD) affects over 15% of Americans and results in an increased risk of skeletal fractures and fracture-related mortality. However, there remain great challenges in estimating fracture risk in CKD patients, as conventional metrics such as bone density assess bone quantity without accounting for the material quality of the bone tissue. The purpose of this review is to highlight the detrimental effects of advanced glycation end products (AGEs) on the structural and mechanical properties of bone, and to demonstrate the importance of including bone quality when assessing fracture risk in CKD patients.

中文翻译：

---

晚期糖基化终末产物对慢性肾病骨特性的影响。

超过 15% 的美国人患有慢性肾病 (CKD)，并导致骨骼骨折和骨折相关死亡率的风险增加。然而，估计 CKD 患者的骨折风险仍然存在巨大挑战，因为骨密度等传统指标评估骨量时没有考虑骨组织的材料质量。本综述的目的是强调晚期糖基化终末产物 (AGE) 对骨骼结构和机械性能的有害影响，并证明在评估 CKD 患者骨折风险时纳入骨质量的重要性。