Lung adenocarcinomas are more common in non-smoking males and females. In this study, we investigated the function of long non-coding RNA RMRP in lung adenocarcinoma and further explore the regulatory role of ALKBH5 in lncRNA methylation. The results showed lncRNA RMRP expression was significantly enhanced in lung adenocarcinoma tissues, and is positively correlated with poor prognosis. RMRP knockdown in lung adenocarcinoma cell lines suppressed cell proliferation, migration and invasion, and promoted cell apoptosis. In addition, ALKBH5 upregulated RMRP expression via demethylation, and ALKBH5 knockdown inhibited the tumorigenesis of lung adenocarcinoma in vitro and vivo. Given these clear patterns, suppressing RMRP through ALKBH5 manipulation may represent a promising therapeutic target for lung adenocarcinoma.

肺腺癌在不吸烟的男性和女性中更常见。在本研究中，我们研究了长链非编码 RNA RMRP 在肺腺癌中的功能，并进一步探讨了 ALKBH5 在 lncRNA 甲基化中的调节作用。结果显示，lncRNA RMRP在肺腺癌组织中的表达显着增强，与预后不良呈正相关。肺腺癌细胞系中 RMRP 的敲低抑制了细胞增殖、迁移和侵袭，并促进了细胞凋亡。此外，ALKBH5 通过去甲基化上调 RMRP 表达，并且 ALKBH5 敲低在体外和体内抑制了肺腺癌的肿瘤发生。鉴于这些明确的模式，通过 ALKBH5 操作抑制 RMRP 可能代表肺腺癌的有希望的治疗靶点。