Increasing evidence from epidemiological, animal and in vitro studies suggests that the increased production of synthetic chemicals that interfere with the proper functioning of the hormonal system, so-called endocrine-disrupting compounds (EDCs), might be involved in the development and rapid spread of obesity, coined the obesity epidemic. Recent findings have demonstrated that EDCs may interfere with hormonal receptors that regulate adipogenesis and metabolic pathways. Furthermore, prenatal exposure to EDCs has been shown to influence the metabolism of the developing embryo through epigenetic mechanisms and to promote obesity in subsequent generations. In this Review, we discuss the potential impact of bisphenol A (BPA) and phthalate-based plasticizers on obesity and obesity-related metabolic disorders. Special emphasis is given to the obesogenic effects of prenatal exposure and strategies for identifying, regulating, and replacing EDCs.

越来越多的流行病学、动物和体外证据研究表明，干扰荷尔蒙系统正常功能的合成化学物质的产量增加，即所谓的内分泌干扰化合物 (EDC)，可能与肥胖的发展和迅速蔓延有关，从而导致了肥胖流行。最近的研究结果表明，EDCs 可能会干扰调节脂肪生成和代谢途径的激素受体。此外，产前暴露于 EDC 已被证明会通过表观遗传机制影响发育中胚胎的代谢，并促进后代肥胖。在这篇综述中，我们讨论了双酚 A (BPA) 和邻苯二甲酸酯类增塑剂对肥胖和肥胖相关代谢紊乱的潜在影响。特别强调产前暴露的致胖效应和识别、