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Magnetophoretic Decoupler for Disaggregation and Interparticle Distance Control
Advanced Science ( IF 14.3 ) Pub Date : 2021-05-01 , DOI: 10.1002/advs.202100532 Hyeonseol Kim 1 , Byeonghwa Lim 1 , Jonghwan Yoon 1 , Keonmok Kim 1 , Sri Ramulu Torati 1 , CheolGi Kim 1
Advanced Science ( IF 14.3 ) Pub Date : 2021-05-01 , DOI: 10.1002/advs.202100532 Hyeonseol Kim 1 , Byeonghwa Lim 1 , Jonghwan Yoon 1 , Keonmok Kim 1 , Sri Ramulu Torati 1 , CheolGi Kim 1
Affiliation
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The manipulation of superparamagnetic beads has attracted various lab on a chip and magnetic tweezer platforms for separating, sorting, and labeling cells and bioentities, but the irreversible aggregation of beads owing to magnetic interactions has limited its actual functionality. Here, an efficient solution is developed for the disaggregation of magnetic beads and interparticle distance control with a magnetophoretic decoupler using an external rotating magnetic field. A unique magnetic potential energy distribution in the form of an asymmetric magnetic thin film around the gap is created and tuned in a controlled manner, regulated by the size ratio of the bead with a magnetic pattern. Hence, the aggregated beads are detached into single beads and transported in one direction in an array pattern. Furthermore, the simultaneous and accurate spacing control of multiple magnetic bead pairs is performed by adjusting the angle of the rotating magnetic field, which continuously changes the energy well associated with a specific shape of the magnetic patterns. This technique offers an advanced solution for the disaggregation and controlled manipulation of beads, can allow new possibilities for the enhanced functioning of lab on a chip and magnetic tweezers platforms for biological assays, intercellular interactions, and magnetic biochip systems.
中文翻译：
用于解聚和颗粒间距离控制的磁泳解耦器
超顺磁珠的操纵吸引了各种芯片实验室和磁镊平台用于分离、分选和标记细胞和生物实体，但由于磁相互作用而导致的磁珠不可逆聚集限制了其实际功能。在这里，开发了一种有效的解决方案，用于使用外部旋转磁场通过磁泳解耦器来分解磁珠和控制颗粒间距离。以受控方式创建和调整间隙周围不对称磁性薄膜形式的独特磁势能分布，并通过具有磁性图案的珠子的尺寸比进行调节。因此，聚集的珠子被分离成单个珠子并以阵列模式沿一个方向运输。此外，通过调节旋转磁场的角度来同时精确地控制多个磁珠对的间距，从而连续地改变与磁图案的特定形状相关的能量井。该技术为珠子的分解和受控操作提供了先进的解决方案，可以为增强芯片实验室和用于生物测定、细胞间相互作用和磁性生物芯片系统的磁镊平台的功能提供新的可能性。
更新日期：2021-06-24
中文翻译：
用于解聚和颗粒间距离控制的磁泳解耦器
超顺磁珠的操纵吸引了各种芯片实验室和磁镊平台用于分离、分选和标记细胞和生物实体，但由于磁相互作用而导致的磁珠不可逆聚集限制了其实际功能。在这里，开发了一种有效的解决方案，用于使用外部旋转磁场通过磁泳解耦器来分解磁珠和控制颗粒间距离。以受控方式创建和调整间隙周围不对称磁性薄膜形式的独特磁势能分布，并通过具有磁性图案的珠子的尺寸比进行调节。因此，聚集的珠子被分离成单个珠子并以阵列模式沿一个方向运输。此外，通过调节旋转磁场的角度来同时精确地控制多个磁珠对的间距，从而连续地改变与磁图案的特定形状相关的能量井。该技术为珠子的分解和受控操作提供了先进的解决方案，可以为增强芯片实验室和用于生物测定、细胞间相互作用和磁性生物芯片系统的磁镊平台的功能提供新的可能性。
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