Aortic fenestration (AF) uses puncture and a dilation balloon to create a tear in the intimal flap, which can directly relieve ischemia syndrome and reduce hypertension in the false lumen. The selection of a dilation balloon as well as the area of the created tear applied in reality depend on clinical experience, so we aim to provide a quantitative guidance and reference for doctors to better plan the treatment of aortic fenestration. In this study, the area of the created tear was virtually enlarged to at least 10 different values for four cases including one ideal case, and a computational fluid dynamic approach was applied to simulate blood flows in the aorta. The area ratio (AR) between the created tear and entry tear was introduced to express the enlargement of the created tear. The quantitative hemodynamic results indicate that the AR should be controlled to be larger than 7.0, but not too big to obtain the best treatment for acute aortic dissection (AD) case. Additionally, we assessed that AR might also be a risk factor for the prediction of dissection propagation.

中文翻译：

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基于计算流体动力学的主动脉开窗治疗创泪面积指南

主动脉开窗术 (AF) 使用穿刺和扩张球囊在内膜瓣中产生撕裂，可直接缓解缺血综合征并降低假腔内的高血压。扩张球囊的选择以及实际应用的撕裂区域取决于临床经验，旨在为医生更好地规划主动脉开窗治疗提供量化的指导和参考。在这项研究中，四个病例（包括一个理想病例）的撕裂面积实际上扩大到至少 10 个不同的值，并应用计算流体动力学方法来模拟主动脉中的血流。引入了产生的撕裂和入口撕裂之间的面积比 (AR) 来表示产生的撕裂的扩大。定量血流动力学结果表明，AR应控制在7.0以上，但不能太大，以获得急性主动脉夹层（AD）病例的最佳治疗。此外，我们评估 AR 也可能是预测解剖传播的风险因素。