Prediction of hyperketonemia (HYK), a postpartum metabolic disorder in dairy cows, through use of cow and milk data has allowed for high-throughput detection and monitoring during monthly milk sampling. The objective of this study was to determine associations between predicted HYK (pHYK) and production parameters in a dataset generated from routine milk analysis samples. Data from 240,714 lactations across 335 farms were analyzed with multiple linear regression models to determine HYK status. Data on HYK or disease treatment was not solicited. Consistent with past research, pHYK cows had greater previous lactation dry period length, somatic cell count, and dystocia. Cows identified as pHYK had lower milk yield and protein percent but greater milk fat, specifically greater mixed and preformed fatty acids (FA), and greater somatic cell count (SCC). Differential somatic cell count was greater in second and fourth parity pHYK cows. Culling (60d), days open, and number of artificial inseminations were greater in pHYK cows. Hyperketonemia prevalence decreased linearly in herds with greater rolling herd average milk yield. This research confirms previously identified risk factors and negative outcomes associated with pHYK and highlights novel associations with differential SCC, mixed FA, and preformed FA across farm sizes and production levels.

中文翻译：

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高血钾症预测提供了具有流行病学见解的农场管理工具

通过使用奶牛和牛奶数据，对奶牛产后代谢异常高酮血症（HYK）的预测可以在每月牛奶采样中进行高通量检测和监测。这项研究的目的是确定由常规牛奶分析样品产生的数据集中的预测HYK（pHYK）与生产参数之间的关联。使用多个线性回归模型分析了来自335个农场的240,714次泌乳的数据，以确定HYK状况。没有收集关于HYK或疾病治疗的数据。与过去的研究一致，pHYK母牛以前的泌乳干燥期长度，体细胞数和难产性都更高。鉴定为pHYK的奶牛的牛奶产量和蛋白质百分比较低，但牛奶脂肪较高，特别是混合和预先形成的脂肪酸（FA）较高，而体细胞计数（SCC）也较高。在第二和第四胎的pHYK奶牛中，体细胞差异计数更高。pHYK母牛的淘汰（60天），开放天数和人工授精数量更多。牛群的高酮血症患病率呈线性下降，而牛群的平均产奶量更高。这项研究证实了先前确定的与pHYK相关的风险因素和负面结果，并强调了与农场规模和生产水平不同的SCC，混合FA和预制FA的新颖关联。