Background There is increasing evidence that patterns of pubertal maturation are associated with different patterns of health risk. This study aimed to explore the associations between anthropometric measures and salivary androgen concentrations in pre-adolescent children. Methods We analysed a stratified random sample (N=1151) of pupils aged 8–9 years old from 43 primary schools in Melbourne, Australia from the Childhood to Adolescence Transition Study. Saliva samples were assayed for dehydroepiandrosterone (DHEA), DHEA-sulfate and testosterone. Anthropometric measures included height, weight, body mass index (BMI) and waist circumference. Associations between (1) anthropometric measures and each androgen, and (2) hormone status with obesity and parental report of pubertal development were investigated using linear regression modelling with general estimating equations. Results Greater height, weight, BMI and waist circumference were positively associated with higher androgen concentrations, after adjusting for sex and socioeconomic status. Being overweight or obese was associated with higher testosterone and DHEA concentrations compared with the normal BMI category. Those who were obese were more likely (OR=2.7, 95% CI 1.61 to 4.43, p<0.001) to be in the top tertile of age-adjusted androgen status in both sexes. Conclusion This study provides clear evidence for an association between obesity and higher androgen levels in mid-childhood. The adrenal transition may be a critical time period for weight management intervention strategies in order to manage the risk for metabolic problems in later life for high-risk individuals. Data are available upon reasonable request. Data are part of the Childhood to Adolescence Transition Study (CATS) . Requests to access the data should be directed to the study team: CATS Murdoch Children’s Research Institute, The Royal Children’s Hospital, Flemington Road Parkville VIC 3052 Australia. Tel: (03) 9345 6732 / 0410 636 104 Email: cats@mcri.edu.au.

中文翻译：

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生长和肾上腺素分泌：CATS 观察性研究的结果

背景 越来越多的证据表明，青春期成熟的模式与不同的健康风险模式相关。本研究旨在探讨人体测量指标与青春期前儿童唾液雄激素浓度之间的关联。方法 我们对澳大利亚墨尔本 43 所小学的 8-9 岁学生的分层随机样本 (N=1151) 进行了从童年到青春期过渡研究的分析。对唾液样品进行脱氢表雄酮 (DHEA)、DHEA-硫酸盐和睾酮分析。人体测量指标包括身高、体重、体重指数 (BMI) 和腰围。(1) 人体测量与每种雄激素之间的关联，(2) 使用线性回归模型和一般估计方程研究肥胖和父母对青春期发育的报告的激素状态。结果在调整性别和社会经济地位后，较高的身高、体重、BMI 和腰围与较高的雄激素浓度呈正相关。与正常 BMI 类别相比，超重或肥胖与较高的睾酮和 DHEA 浓度相关。肥胖者更有可能（OR=2.7，95% CI 1.61 至 4.43，p<0.001）在两性中均处于年龄调整雄激素状态的前三分位数。结论 这项研究为肥胖与儿童中期较高的雄激素水平之间的关联提供了明确的证据。肾上腺过渡可能是体重管理干预策略的关键时期，以便管理高危个体晚年代谢问题的风险。可应合理要求提供数据。数据是童年到青春期过渡研究 (CATS) 的一部分. 访问数据的请求应提交给研究团队：CATS Murdoch Children's Research Institute, The Royal Children's Hospital, Flemington Road Parkville VIC 3052 Australia。电话：(03) 9345 6732 / 0410 636 104 电子邮件：cats@mcri.edu.au。