Betanodavirus infections have been associated with significant economic losses in Mediterranean marine aquaculture due to viral nervous necrosis (VNN). Recently, RGNNV/SJNNV reassortant betanodavirus has been reported as a possible cause of disease in Sparus aurata.

In this study, mortality events occurred in cultured gilthead sea bream from 19 to 26 days of age, coming from an Italian aquaculture farm are described. Samples of diseased larvae were collected and underwent histopathological, bacteriological and virological analyses.

Lesions related to VNN and larval enteropathy (LE) were found. The isolates were identified as RGNNV/SJNNV reassortant betanodavirus and Vibrio alginolyticus. With the present study, to our knowledge, we describe for the first time the co-occurrence of VNN and LE, which, in synergy or simultaneously, elicited a mortality outbreak of Sparus aurata larvae.

由于病毒神经坏死（VNN），Betanodavirus感染已在地中海海水养殖中造成重大经济损失。近来，已经报道了RGNNV / SJNNV重配品扁豆病毒是Sparus aurata中可能的疾病原因。

在这项研究中，描述了来自意大利水产养殖场的19至26日龄养殖的金头鲷发生的死亡事件。收集患病幼虫的样品，并进行组织病理学，细菌学和病毒学分析。

发现与VNN和幼虫肠病（LE）有关的病变。分离株被鉴定为RGNNV / SJNNV重配品贝达病毒和溶藻弧菌。根据目前的研究，就我们所知，我们首次描述了VNN和LE的共存，这两者协同或同时引发了金枪鱼幼虫的死亡。