Objective

To evaluate the effects of dexmedetomidine alone or in combination with different opioids on intraocular pressure (IOP) in dogs.

Study design

Experimental, prospective, crossover, randomized, blinded study.

Animals

A total of six Beagle dogs (two males and four females) aged 2 years and weighing 15.9 ± 2.9 kg (mean ± standard deviation).

Methods

Dogs were distributed randomly into seven treatments (n = 6 per treatment) and were administered dexmedetomidine alone (10 μg kg^–1; Dex) or in combination with butorphanol (0.15 mg kg^–1; DexBut), meperidine (5 mg kg^–1; DexMep), methadone (0.5 mg kg^–1; DexMet), morphine (0.5 mg kg^–1; DexMor), nalbuphine (0.5 mg kg^–1; DexNal) or tramadol (5 mg kg^–1; DexTra). All drugs were administered intramuscularly. IOP was measured before drug injection (time 0, baseline) and every 15 minutes thereafter for 120 minutes (T15–T120).

Results

There were significant reductions in IOP compared with baseline in treatments Dex and DexMep at times T30–T120, and in treatment DexMet at T15–T90. IOP decreased compared with baseline in treatments DexBut, DexNal and DexTra at all evaluation times. No changes in IOP were seen in treatment DexMor. The mean IOP values in treatment DexMet at T105–T120 were higher than those for other treatments.

Conclusions and clinical relevance

Dexmedetomidine alone or in combination with butorphanol, meperidine, methadone, nalbuphine or tramadol resulted in decreased IOP for 120 minutes in dogs. The magnitude of the reduction was small and lacked clinical significance.

中文翻译：

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右美托咪定单独或与阿片类药物联合对健康比格犬眼压的影响

客观的

评估单独使用右美托咪定或与不同阿片类药物联合使用对狗眼压 (IOP) 的影响。

学习规划

实验性、前瞻性、交叉、随机、盲法研究。

动物

共有六只比格犬（两只雄性和四只雌性）年龄为 2 岁，体重为 15.9 ± 2.9 公斤（平均值 ± 标准差）。

方法

将狗随机分配到 7 个治疗组（每个治疗组n  = 6），单独给予右美托咪定（10 μg kg ^-1；Dex）或与布托啡诺（0.15 mg kg ^-1；DexBut）、哌替啶（5 mg kg ^-1 ; DexMep)、美沙酮 (0.5 mg kg ^–1 ; DexMet)、吗啡 (0.5 mg kg ^–1 ; DexMor)、纳布啡 (0.5 mg kg ^–1 ; DexNal) 或曲马多 (5 mg kg ^–1 ; DexTra)。所有药物均肌肉内给药。在药物注射前（时间 0，基线）测量眼压，之后每 15 分钟测量 120 分钟（T15-T120）。

结果

与基线相比，在 T30-T120 时间的 Dex 和 DexMep 治疗以及 T15-T90 的 DexMet 治疗的眼压显着降低。在所有评估时间，与 DexBut、DexNal 和 DexTra 治疗的基线相比，眼压下降。在治疗 DexMor 中没有观察到眼压的变化。在 T105-T120 治疗 DexMet 的平均眼压值高于其他治疗。

结论和临床相关性

右美托咪定单独或与布托啡诺、哌替啶、美沙酮、纳布啡或曲马多联合使用可导致犬眼压降低 120 分钟。减少的幅度很小，缺乏临床意义。