Abstract

The base and nucleotide excision DNA repair (BER and NER) systems are aimed at removing specific types of damaged DNA, i.e., oxidized, alkylated, or deaminated bases in the case of BER and bulky damage caused by UV radiation or chemical carcinogens in the case of NER. In some cases, however, the repair process follows a more complex scenario, which implies that the repair pathways exchange proteins and interact with each other to form a common interactome. This review describes the BER and NER mechanisms and discusses the current data on the involvement of the NER proteins in the repair of DNA lesions caused by oxidative stress and the BER proteins in the removal of bulky DNA adducts. We also discuss the role of poly(ADP-ribose) polymerase 1 in the regulation of the BER and NER processes and their coordination in the repair of complex (cluster) lesions.

中文翻译：

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碱基和核苷酸切除DNA修复系统的相互作用

摘要

碱基和核苷酸切除DNA修复（BER和NER）系统的目的是去除特定类型的受损DNA，例如在BER的情况下被氧化，烷基化或脱氨基的碱基，在这种情况下则是由UV辐射或化学致癌物引起的大面积损坏NER。但是，在某些情况下，修复过程遵循的是更复杂的情况，这意味着修复途径交换蛋白质并彼此相互作用以形成共同的相互作用组。这篇综述描述了BER和NER机制，并讨论了有关NER蛋白参与修复由氧化应激引起的DNA损伤和BER蛋白参与去除庞大的DNA加合物的最新数据。