Natural killer (NK) cells are paramount for immunity against infectious agents and tumors. Their cytokine and cytolytic responses can be mediated by natural killer group 2, member D (NKG2D), an activating receptor whose ligands (NKG2DL) expression is induced in conditions of cell stress and malignant transformation. Since sustained expression of NKG2DL MICA is related to lower survival rates in gastric adenocarcinoma patients, and Helicobacter pylori infection contributes to tumorigenesis; we asked whether H. pylori stimulus could promote NKG2DL expression on human gastric adenocarcinoma cells.

中文翻译：

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热灭活的幽门螺杆菌通过 Toll 样受体 4 上调胃腺癌细胞上 NKG2D 配体的表达

自然杀伤 (NK) 细胞对于抵抗传染源和肿瘤的免疫力至关重要。它们的细胞因子和溶细胞反应可以由自然杀伤组 2 成员 D (NKG2D) 介导，这是一种激活受体，其配体 (NKG2DL) 表达在细胞应激和恶性转化条件下被诱导。由于 NKG2DL MICA 的持续表达与胃腺癌患者较低的存活率有关，而幽门螺杆菌感染有助于肿瘤发生；我们问是否H . pylori刺激可以促进人胃腺癌细胞上 NKG2DL 的表达。