Paranoia manifests similarly in subclinical and clinical populations and is related to distress and impairment. Previous work links paranoia to amygdala hyperactivity and reduced activation of the ventrolateral prefrontal cortex (VLPFC), a region thought to regulate amygdala activity.

中文翻译：

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单次经颅直流电刺激腹外侧前额叶皮层可减少健康个体亚临床偏执狂的初步证据

偏执狂在亚临床和临床人群中的表现相似，并且与痛苦和损害有关。以前的工作将妄想症与杏仁核过度活跃和腹外侧前额叶皮层 (VLPFC) 的激活减少联系起来，该区域被认为可以调节杏仁核的活动。