Abstract

1. Non-essential heavy metals such as mercury (Hg), arsenic (As), cadmium (Cd), and aluminium (Al) are useless to organisms and have shown extensive toxic effects. Previous studies show that two main molecular mechanisms of metal toxicity are oxidative stress and metal-metal interaction which can disrupt metal homeostasis.

2. In this paper, we mainly illustrate metal toxicity and metal-metal interaction through examples in mammalians and D. melanogaster (fruit fly).

3. We describe the interference of metal homeostasis by metal-metal interactions in three aspects including replacement, cellular transporter competition, and disruption of the regulation mechanism, and elaborate the mechanisms of metal toxicity to better deal with the challenges of heavy metal pollution and related health problems.

摘要

1. 非必需重金属如汞 (Hg)、砷 (As)、镉 (Cd) 和铝 (Al) 对生物体无用，并已显示出广泛的毒性作用。先前的研究表明，金属毒性的两个主要分子机制是氧化应激和金属-金属相互作用，它们可以破坏金属稳态。

2. 在本文中，我们主要通过哺乳动物和黑腹果蝇（果蝇）的例子来说明金属毒性和金属-金属相互作用。

3. 我们从置换、细胞转运体竞争和调控机制的破坏三个方面描述了金属-金属相互作用对金属稳态的干扰，并阐述了金属毒性的机制，以更好地应对重金属污染和相关问题的挑战。健康问题。