The function of Casein kinase 2 beta (CSNK2B) in human malignancies has drawn increasing attention in recent years. However, its role in colorectal cancer (CRC) remains unclear. In the present study, we aimed to explore the expression and biological functions of CSNK2B in CRC. Public gene expression microarray data from online database and immunohistochemistry analysis demonstrated that CSNK2B was highly expressed in CRC tissues than in normal tissues. In vitro and in vivo cellular functional experiments showed that increased CSNK2B expression promoted CRC cell viability and tumorigenesis of CRC. Further western blots and rescue experiments confirmed that CSNK2B promoted CRC cell proliferation mainly by activating the mTOR signaling pathway. These findings identified CSNK2B as a novel oncogene contributing to the development of CRC.

酪蛋白激酶2β（CSNK2B）在人类恶性肿瘤中的功能近年来引起了越来越多的关注。然而，其在结直肠癌（CRC）中的作用仍不清楚。在本研究中，我们旨在探讨CSNK2B在CRC中的表达及其生物学功能。来自在线数据库和免疫组织化学分析的公共基因表达微阵列数据表明，CSNK2B在CRC组织中的表达高于正常组织。体外和体内细胞功能实验表明，增加的CSNK2B表达可促进CRC细胞的活力和CRC的肿瘤发生。进一步的免疫印迹和救援实验证实CSNK2B主要通过激活mTOR信号通路来促进CRC细胞增殖。这些发现确定CSNK2B是一种新型的致癌基因，有助于CRC的发展。