Asymmetric Hydrogenation: Design of Chiral Ligands and Transition Metal Complexes. Synthetic and Industrial Applications.,Israel Journal of Chemistry

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Asymmetric Hydrogenation: Design of Chiral Ligands and Transition Metal Complexes. Synthetic and Industrial Applications.
Israel Journal of Chemistry ( IF 2.3 ) Pub Date : 2021-04-29 , DOI: 10.1002/ijch.202100023
Jean‐Pierre Genêt ₁ , Phannarath Phansavath ₁ , Virginie Ratovelomanana‐Vidal ₁

Affiliation

This personal account focuses on the development of atropisomeric ligands and chiral transition metal complexes and their applications to the asymmetric hydrogenation of alkenes, ketones and heteroaromatics using Ru(II) and Ir(III) catalysts in-house developed. Particularly, effective scaled-up development syntheses of SYNPHOS and DIFLUORPHOS have been successfully achieved and their steric and electronic profiling established. Going further, we demonstrated the utility of such homogeneous catalytic process highlighted with examples of industrial applications and total syntheses of biorelevant targets. Asymmetric hydrogenation provides a powerful tool for performing precise stereocontrolled transformations on valuable complex molecules.

中文翻译：

不对称氢化：手性配体和过渡金属配合物的设计。合成和工业应用。

该个人帐户侧重于阻转异构配体和手性过渡金属配合物的开发及其在使用内部开发的 Ru(II) 和 Ir(III) 催化剂的烯烃、酮和杂芳烃不对称氢化中的应用。特别是，SYNPHOS 和 DIFLUORPHOS 的有效放大开发合成已经成功实现，并建立了它们的空间和电子分析。更进一步，我们展示了这种均相催化过程的实用性，并通过工业应用和生物相关目标的全合成示例进行了强调。不对称氢化为对有价值的复杂分子进行精确的立体控制转化提供了强大的工具。

更新日期：2021-04-29

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