Surgical post-operative adhesions can lead to serious clinical complications. Barrier agent is the broad usage for the prevention of post-operative adhesions. This study aimed to evaluate the reducing adhesion efficacy of non-animal hyaluronic acid (HA) hydrogel in pigs undergoing conventional laparotomy pelvic surgery. HA hydrogel was applied to eighteen female pigs who underwent conventional laparotomy. The adhesion degrees and histopathology were evaluated in bilateral uterine horns as well as peritoneal sidewall excision. In the present study, all animals survived and had no complications after the surgery. The histopathological observations were demonstrated that HA obviously improved laparotomy pelvic surgery-induced adhesion in peritoneal sidewall and uterine horn. The anastomotic healing score of injury + HA group was significantly lower than the injury alone group. We conclude HA hydrogel can attenuate the post-operative adhesions in porcine.

手术后粘连可导致严重的临床并发症。阻隔剂是预防术后粘连的广泛用途。本研究旨在评估非动物透明质酸 (HA) 水凝胶对接受常规剖腹盆腔手术的猪的降低粘连效果。HA 水凝胶应用于 18 头接受常规剖腹手术的雌性猪。在双侧子宫角以及腹膜侧壁切除术中评估粘连程度和组织病理学。在本研究中，所有动物在手术后都存活并且没有并发症。组织病理学观察表明，HA明显改善了剖腹盆腔手术引起的腹膜侧壁和子宫角粘连。损伤+HA组吻合口愈合评分明显低于单纯损伤组。我们得出的结论是 HA 水凝胶可以减轻猪的术后粘连。