Cancer of the reproductive tract includes diseases with higher prevalence in the female population. This investigation examined whether an anthocyanin-enriched extract of Aristotelia chilensis, commonly known as “maqui,” could affect some hallmarks of endometrial cancer. Cultures of the human endometrial cancer cell line Ishikawa were treated with a hydroethanolic maqui extract at 1, 3, 10, 30, 100, 300, or 1000 µg/mL to determine the effect on cell viability by MTT assay. Then, we used the 50% Effective Concentration (EC50) to evaluate whether the effect of the maqui extract is mediated via an arrest of the cell cycle or induction of apoptosis using flow cytometry or Annexin V-FITC assays, respectively. The effects of sublethal doses of the maqui extract on migration and invasiveness of Ishikawa cells were also evaluated by the wound healing and Boyden Chamber assay, respectively. Our results show that the hydroethanolic maqui extract inhibits the cell viability with an EC50 of 472.3 µg/mL via increased apoptosis, and that reduces the invasive capacity but not migration of Ishikawa cells. These findings suggest that the hydroethanolic maqui extract has antineoplastic properties for endometrial cancer and merits further studies to corroborate its efficiency as anticancer therapy in reproductive organs.

生殖道癌症包括在女性人群中患病率较高的疾病。这项调查检查了富含花青素的智利亚里士多德提取物（通常称为“maqui”）是否会影响子宫内膜癌的某些特征。用 1、3、10、30、100、300 或 1000 µg/mL 的水乙醇马基提取物处理人子宫内膜癌细胞系 Ishikawa 的培养物，以通过 MTT 测定确定对细胞活力的影响。然后，我们使用 50% 有效浓度 (EC50) 来评估马基提取物的作用是否是通过细胞周期停滞或使用流式细胞术或膜联蛋白V诱导细胞凋亡来介导的-FITC 测定，分别。还分别通过伤口愈合和博伊登室试验评估了亚致死剂量的马基提取物对石川细胞迁移和侵袭性的影响。我们的结果表明，马基水乙醇提取物通过增加细胞凋亡抑制细胞活力，EC50 为 472.3 µg/mL，这会降低 Ishikawa 细胞的侵袭能力，但不会降低其迁移。这些发现表明，马基水乙醇提取物对子宫内膜癌具有抗肿瘤特性，值得进一步研究以证实其作为生殖器官抗癌治疗的有效性。