The ability to prevent or minimize the accumulation of unwanted biological materials on implantable medical devices is important in maintaining the long-term function of implants. To address this issue, there has been a focus on materials, both biological and synthetic, that have the potential to prevent device fouling. In this review, we introduce a glycoprotein called lubricin and report on its emergence as an effective antifouling coating material. We outline the versatility of lubricin coatings on different surfaces, describe the physical properties of its monolayer structures, and highlight its antifouling properties in improving implant compatibility as well as its use in treatment of ocular diseases and arthritis. This review further describes synthetic polymers mimicking the lubricin structure and function. We also discuss the potential future use of lubricin and its synthetic mimetics as antiadhesive biomaterials for therapeutic applications.

中文翻译：

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Lubricin 作为控制体内和体内粘附的工具

防止或最小化不需要的生物材料在可植入医疗设备上的积累对于保持植入物的长期功能很重要。为了解决这个问题，人们一直关注具有防止设备污染潜力的生物和合成材料。在这篇综述中，我们介绍了一种称为 lubricin 的糖蛋白，并报告了它作为一种有效的防污涂层材料的出现。我们概述了润滑素涂层在不同表面上的多功能性，描述了其单层结构的物理特性，并强调了其在改善植入物相容性方面的防污性能以及在治疗眼部疾病和关节炎方面的用途。本综述进一步描述了模拟润滑素结构和功能的合成聚合物。