We present the conducting polymer poly (3,4-ethylenedioxythiophene) (PEDOT) doped with an algal-derived glycan extract, Phycotrix™ [xylorhamno-uronic glycan (XRU84)], as an innovative electrically conductive material capable of providing beneficial biological and electrical cues for the promotion of favorable wound healing processes. Increased loading of the algal XRU84 into PEDOT resulted in a reduced surface nanoroughness and interfacial surface area and an increased static water contact angle. PEDOT-XRU84 films demonstrated good electrical stability and charge storage capacity and a reduced impedance relative to the control gold electrode. A quartz crystal microbalance with dissipation monitoring study of protein adsorption (transferrin, fibrinogen, and collagen) showed that collagen adsorption increased significantly with increased XRU84 loading, while transferrin adsorption was significantly reduced. The viscoelastic properties of adsorbed protein, characterized using the ΔD/Δf ratio, showed that for transferrin and fibrinogen, a rigid, dehydrated layer was formed at low XRU84 loadings. Cell studies using human dermal fibroblasts demonstrated excellent cell viability, with fluorescent staining of the cell cytoskeleton illustrating all polymers to present excellent cell adhesion and spreading after 24 h.

中文翻译：

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纤维蛋白原、胶原蛋白和转铁蛋白吸附到聚（3,4-乙撑二氧噻吩）-木糖胺糖醛聚糖复合导电聚合物生物材料上，用于伤口愈合

我们介绍了导电聚合物聚（3,4-亚乙基二氧噻吩）（PEDOT）掺杂藻类衍生聚糖提取物 Phycotrix™ [木糖苷-糖醛聚糖 (XRU84)]，作为一种创新的导电材料，能够提供有益的生物和电促进有利的伤口愈合过程的线索。藻类 XRU84 在 PEDOT 中的负载增加导致表面纳米粗糙度和界面表面积降低以及静态水接触角增加。PEDOT-XRU84 薄膜表现出良好的电稳定性和电荷存储能力，并且相对于对照金电极具有降低的阻抗。具有蛋白质吸附（转铁蛋白、纤维蛋白原、和胶原蛋白）表明，随着 XRU84 负载量的增加，胶原蛋白吸附显着增加，而转铁蛋白吸附显着降低。吸附蛋白质的粘弹性，用Δ表征D /Δ f比值表明，对于转铁蛋白和纤维蛋白原，在低 XRU84 负载量下形成刚性脱水层。使用人真皮成纤维细胞进行的细胞研究证明了出色的细胞活力，细胞骨架的荧光染色表明所有聚合物在 24 小时后都表现出出色的细胞粘附和扩散。