Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications. In this study, we generate a composite film, using the solution casting approach, from carboxymethyl chitosan (CMC) and magnetite nanoparticles (MNPs). The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy. With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0. Our film warrants further development and optimization as a carrier to mediate pH-responsive bioactive agent release.

中文翻译：

---

羧甲基壳聚糖和磁铁矿纳米颗粒制备的用于pH响应生物活性剂释放的复合膜的开发

开发一种能够实现刺激响应生物活性剂递送的生物相容性薄膜，对于食品和药物应用具有很高的实用价值。在这项研究中，我们使用溶液浇铸方法从羧甲基壳聚糖 (CMC) 和磁铁矿纳米粒子 (MNP) 生成复合膜。CMC、MNPs 和生成的薄膜的结构和性质通过使用各种表征技术进行表征，包括傅里叶变换红外光谱、差示扫描量热法、热重分析、X 射线衍射光谱和扫描电子显微镜。使用多柔比星 (DOX) 作为模型药剂，发现当p周围介质的 H 从 7.4 变为 5.0。我们的薄膜需要进一步开发和优化，作为介导p H 响应性生物活性剂释放的载体。