In the last two decades, there has been a strong research interest in producing radioisotopes with ultra-intense lasers, as an application of laser-driven accelerators in nuclear medicine. Encouraging progress has been obtained in both experiments and simulations. This Review presents the results of several intense studied radioisotopes in detail, i.e., ¹⁸F, ¹¹C, ¹³N, ¹⁵O, ^99mTc, ⁶⁴Cu, and ⁶²Cu. As for other less studied radioisotopes, the results are summarized in Sec. II G. The results are listed in Tables I–VII along with laser intensities, maximum ion/photon energies, number of ions/photons per shot, reactions, and laser repetition rates and facilities. For research based on high repetition rate lasers, both single-shot and multi-shot productions are provided for the purpose of comparison. With key technologies implemented in new commissioning ultra-intense lasers, further experiments will definitely help moving this area forward, which will bring the realization of laser-driven radioisotope production closer.

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评论：利用超高强度激光生产核医学放射性同位素

在过去的二十年中，作为激光驱动加速器在核医学中的应用，人们对利用超高强度激光生产放射性同位素有着强烈的研究兴趣。在实验和模拟中都获得了令人鼓舞的进展。这篇评论详细介绍了几种经过深入研究的放射性同位素的结果，即¹⁸ F，¹¹ C，¹³ N，¹⁵ O，^{99 m} Tc，⁶⁴ Cu和⁶²铜 至于其他研究较少的放射性同位素，其结果总结于Sec。II G.结果与激光强度，最大离子/光子能量，每次发射的离子/光子数，反应以及激光重复频率和设备一起列在表I-VII中。对于基于高重复频率激光器的研究，提供了单发和多发产品以进行比较。通过在新调试的超高强度激光器中实施关键技术，进一步的实验必将有助于推动这一领域的发展，这将使实现激光驱动的放射性同位素的生产更加接近。