Objective

A meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of pulmonary rehabilitation on functional capacity and quality of life in interstitial lung diseases, including those caused by coronaviruses.

Data Sources

MEDLINE, EMBASE, SPORTDiscus, Cochrane Library, Web of Science, and MedRxiv from inception to November 2020 were searched to identify documents.

Study Selection

Publications investigating the effect of pulmonary rehabilitation on lung function (forced vital capacity [FVC]), exercise capacity (6-minute walk distance [6MWD]), health related quality of life (HRQOL), and dyspnea were searched.

Data Extraction

The data were extracted into predesigned data extraction tables. Risk of bias was evaluated with the Cochrane Risk of Bias tool (RoB 2.0).

Data Synthesis

A total of 11 RCTs with 637 interstitial lung disease patients were eligible for analyses. The pooled effect sizes of the association for pulmonary rehabilitation were 0.37 (95% confidence interval [CI], 0.02-0.71) for FVC, 44.55 (95% CI, 32.46-56.64) for 6MWD, 0.52 (95% CI, 0.22-0.82) for HRQOL, and 0.39 (95% CI, –0.08 to 0.87) for dyspnea. After translating these findings considering clinical improvements, pulmonary rehabilitation intervention increased predicted FVC by 5.5%, the 6MWD test improved by 44.55 m, and HRQOL improved by 3.9 points compared with baseline values. Results remained similar in sensitivity analyses.

Conclusions

Although specific evidence for pulmonary rehabilitation of coronavirus disease 2019 patients has emerged, our data support that interstitial lung disease rehabilitation could be considered as an effective therapeutic strategy to improve the functional capacity and quality of life in this group of patients.

中文翻译：

---

肺康复治疗间质性肺疾病（包括冠状病毒疾病）的有效性：系统评价和荟萃分析

 客观的

对随机对照试验（RCT）进行荟萃分析，以确定肺康复对间质性肺疾病（包括由冠状病毒引起的疾病）的功能能力和生活质量的影响。

 数据来源

对 MEDLINE、EMBASE、SPORTDiscus、Cochrane Library、Web of Science 和 MedRxiv 从成立到 2020 年 11 月期间进行了检索以识别文档。

 研究选择

检索了调查肺康复对肺功能（用力肺活量 [FVC]）、运动能力（6 分钟步行距离 [6MWD]）、健康相关生活质量 (HRQOL) 和呼吸困难影响的出版物。

 数据提取

数据被提取到预先设计的数据提取表中。使用 Cochrane 偏差风险工具 (RoB 2.0) 评估偏差风险。

 数据综合

共有 11 项随机对照试验，涉及 637 名间质性肺病患者，符合分析条件。肺康复相关性的汇总效应大小，FVC 为 0.37（95% 置信区间 [CI]，0.02-0.71），6MWD 为 44.55（95% CI，32.46-56.64），6MWD 为 0.52（95% CI，0.22-0.82） ) 对于 HRQOL，对于呼吸困难为 0.39 (95% CI, –0.08 至 0.87)。将这些研究结果转化为考虑到临床改善后，与基线值相比，肺康复干预使预测用力肺活量 (FVC) 提高了 5.5%，6MWD 测试提高了 44.55 m，HRQOL 提高了 3.9 分。敏感性分析的结果仍然相似。

 结论

尽管2019冠状病毒病患者肺部康复的具体证据已经出现，但我们的数据支持间质性肺疾病康复可被视为改善该组患者功能能力和生活质量的有效治疗策略。