Galectin-3 promotes fibroblast-to-myofibroblast differentiation and facilitates injury repair. Previous studies have shown that exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-ex) promote the differentiation of myocardial fibroblasts into myofibroblasts under inflammatory environment. Whether hucMSC-ex derived Galectin-3 (hucMSC-ex-Galectin-3) plays an important role in fibroblast-to-myofibroblast differentiation is the focus of this study.

中文翻译：

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源自 HucMSC 外泌体的 Galectin-3 促进与 β-连环蛋白上调相关的心肌成纤维细胞向肌成纤维细胞的分化。

Galectin-3 促进成纤维细胞向肌成纤维细胞的分化并促进损伤修复。既往研究表明，人脐带间充质干细胞（hucMSC-ex）来源的外泌体在炎症环境下促进心肌成纤维细胞分化为肌成纤维细胞。hucMSC-ex衍生的Galectin-3（hucMSC-ex-Galectin-3）是否在成纤维细胞向肌成纤维细胞分化中起重要作用是本研究的重点。