Human CD34^＋ hematopoietic stem cells can reconstitute the human hematopoietic system when transplanted into immunocompromised mice after irradiation. Human leukapheresis peripheral blood (LPB)- and cord blood (CB)-derived CD34^＋ cells have a similar capacity to reconstitute myeloid lineage cells in a humanized mice (hu-mice) model. However, potent stem cells, such as CB-CD34^＋ cells, efficiently reconstitute the lymphoid system in vivo compared to LPB-CD34^＋ cells. Modeling the human hematolymphoid system is vital for studying immune cell crosstalk in human xenografted mice, with CB-CD34^＋ cells used as an optimized cell source because they are essential in reconstituting lymphoid lineage cells.

中文翻译：

---

CB-和LPB-CD34＋细胞在Hu-小鼠中通过转录因子富集的不同再增殖活性。

人CD34 ^＋造血干细胞在照射后移植到免疫功能低下的小鼠体内可以重建人的造血系统。人白细胞分离术外周血 (LPB) 和脐带血 (CB) 衍生的 CD34 ⁺细胞在人源化小鼠 (hu-mice) 模型中具有相似的重建骨髓谱系细胞的能力。^{然而，与 LPB-CD34 ＋}细胞相比，有效的干细胞，如 CB-CD34 ^＋细胞，能有效地在体内重建淋巴系统。模拟人类造血淋巴系统对于研究人类异种移植小鼠的免疫细胞串扰至关重要，CB-CD34 ^＋细胞用作优化的细胞来源，因为它们对于重建淋巴谱系细胞至关重要。