Dendritic cells (DCs) are administered as immunotherapeutic adjuvants after the completion of standard treatment in most settings. However, our Phase I trial indicated that one patient out of four, who received autologous tumor lysate-pulsed dendritic cell (TLDC) also received cisplatin chemotherapy and experienced complete regression of her lung lesion, continuing to be disease free till date. Hence, the objective of our current study is to evaluate the sustenance or augmentation of immune responses when autologous human papillomavirus positive cervical tumor lysate pulsed DC- are combined with cisplatin, using co-culture assays in vitro.

中文翻译：

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自体宫颈肿瘤裂解物脉冲树突状细胞刺激，随后顺铂处理在体外消除了 FOXP3+ 细胞。

在大多数情况下，完成标准治疗后，树突状细胞 (DC) 作为免疫治疗佐剂给药。然而，我们的 I 期试验表明，四分之一的接受自体肿瘤裂解物脉冲树突细胞 (TLDC) 的患者也接受了顺铂化疗，并经历了肺部病变的完全消退，至今仍无病。因此，我们当前研究的目的是评估自体人乳头瘤病毒阳性宫颈肿瘤裂解物脉冲 DC- 与顺铂结合时免疫反应的维持或增强，使用体外共培养测定。