Diffuse optic imaging is an important biomedical optic research tool. Diffuse optic tomography (DOT) modality needs progressive philosophical approaches for scientific contribution. Technological developments and philosophical approaches should both go forward. Phase-shift based frequency domain diffuse optical tomography (FDDOT) method was well established in the literature. The instruments were tested for brain neurofunctional imaging. A mixture of AC laser intensity and phase data were used at these works. According to those works, deep tissue resolution was improved by only using phase data. Because phase data is only related to the photon mean free path in imaging tissue media. Besides this advantage, laser intensity data is also affected by noisy background light and electrical artifacts. Another most important advantage of only using phase data can be explained as time-resolved temporal change which can be directly related to the phase shift of modulated frequency source. In this work, the FDDOT imaging method which uses phase shift data were tested for simulation. Laser source-driven forward model problem weight matrix simulation data was given to the simple pseudo-inverse-based inverse problem solution algorithm for one inclusion example. The inclusion image was reconstructed and demonstrated successfully. Forward model problem weight functions inside the tissue simulation media were calculated and used based on the phase shifts at the same core modulation frequency. 100 MHz modulation frequency was selected due to its FDDOT standard. 13 sources and 13 detectors were placed on the back-reflected imaging surface. 40 x, y, z cartesian coordinate grid elements were used in the image reconstruction algorithm. Photon absorption coefficient: μ_a = 0.1 cm⁻¹, and scattering coefficient: μ_s = 100 cm⁻¹ values were set for simulation background. One inclusion object was embedded inside the background imaging tissue simulation environment. x, y, z cartesian coordinate grid sizes were selected for 1 μm for each direction. Photon phase shift fluencies were added to the forward model problem. The forward model problem was built according to the frequency domain photon migration diffusion equation (DE) approximation. The pseudoinverse mathematical inverse problem solution function was applied to test the results. The embedded inclusion object was reconstructed successfully with the high-resolution image quality. The philosophical approach has future promising DOT imaging capability. The phase shift version of the FDDOT modality has an important advantage for future purposes.

漫射光学成像是重要的生物医学光学研究工具。弥散性光学层析成像（DOT）方式需要渐进的哲学方法来做出科学贡献。技术发展和哲学方法都应向前发展。在文献中已经很好地建立了基于相移的频域扩散光学层析成像（FDDOT）方法。该仪器进行了脑神经功能成像测试。在这些工作中使用了交流激光强度和相位数据的混合体。根据这些工作，仅使用相位数据就可以改善深层组织的分辨率。因为相位数据仅与成像组织介质中的光子平均自由程有关。除此优点外，激光强度数据还会受到嘈杂的背景光和电伪像的影响。仅使用相位数据的另一个最重要的优势可以解释为时间分辨的时间变化，它与调制频率源的相移直接相关。在这项工作中，对使用相移数据的FDDOT成像方法进行了仿真测试。以一个简单的基于伪逆的逆问题求解算法为例子，给出了激光源驱动的正向模型问题权矩阵仿真数据。包含图像被重建并成功演示。基于相同核心调制频率下的相移，计算并使用了组织仿真介质内部的正向模型问题权重函数。由于其FDDOT标准，选择了100 MHz调制频率。13个光源和13个检测器放置在背向反射的成像表面上。在图像重建算法中使用了40个x，y，z直角坐标网格元素。光子吸收系数：μ 在图像重建算法中使用了40个x，y，z直角坐标网格元素。光子吸收系数：μ 在图像重建算法中使用了40个x，y，z直角坐标网格元素。光子吸收系数：μ_a  = 0.1 cm ^-1，散射系数：_μs  = 100 cm ^-1值设置为模拟背景。在背景成像组织模拟环境中嵌入了一个包含对象。每个方向的x，y，z笛卡尔坐标网格大小均选择为1μm。光子相移通量被添加到正向模型问题中。根据频域光子迁移扩散方程（DE）近似建立了正向模型问题。应用伪逆数学逆问题解决函数来测试结果。以高分辨率的图像质量成功地重建了嵌入的包含对象。这种哲学方法具有未来有希望的DOT成像能力。FDDOT模式的相移版本具有重要的优势，可用于将来使用。