Initial optimism regarding the development of COVID-19 vaccines has been tempered by the emergence of new variants of SARS-CoV-2. Will vaccination be able to contain the pandemic? How can we best optimize the limited supplies of vaccines available and what should future COVID-19 vaccines look like? This Comment discusses how the emerging SARS-CoV-2 variants of concern could impact on the hopes of long-term pandemic control through vaccination and the mutations that might be relevant to the design of modified vaccines.

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值得关注的 SARS-CoV-2 变种是否会影响疫苗的前景？


SARS-CoV-2 新变种的出现削弱了最初对 COVID-19 疫苗开发的乐观情绪。疫苗接种能否遏制疫情？我们如何才能最好地优化现有疫苗的有限供应以及未来的 COVID-19 疫苗应该是什么样子？本评论讨论了新出现的 SARS-CoV-2 变体如何影响通过疫苗接种长期控制大流行的希望，以及可能与改良疫苗设计相关的突变。