Abstract

This review presents the current state-of-knowledge concerning thermoresponsive copolymers containing 2-hydroxyethyl methacrylate (HEMA). The thermoresponsive copolymers based on HEMA, HEMA derivatives, and copolymers with modified HEMA units in the chain studied so far are presented. Information about their transition temperature in dilute water or buffer solution and the influence of various factors on their thermoresponsive properties described so far in the literature are reported. The research of the aggregation of HEMA containing thermoresponsive chains concern the morphology and size of nanoparticles formed upon heating. Using the available data, we tried to expose the impact of HEMA content in thermoresponsive chains on thermal properties of the copolymers. Modifications of the HEMA hydroxyl groups led to of thermoresponsive macromolecules with various structures and topologies. New functionality introduced by modification improves properties (stability, biocompatibility, and others) of the polymers and their aggregates. Thermal aggregation of HEMA-based copolymers allowing for the creation of carriers of biologically active substances, we presented in a separate part of the review. The works discussed in the review show significant possibilities for using HEMA in obtaining thermoresponsive polymer materials for medical applications.

摘要

这篇综述介绍了目前关于含有 2-羟乙基甲基丙烯酸酯 (HEMA) 的热响应共聚物的知识状态。介绍了迄今为止研究的基于 HEMA、HEMA 衍生物和在链中具有改性 HEMA 单元的共聚物的热响应共聚物。报道了有关它们在稀水或缓冲溶液中的转变温度的信息以及迄今为止文献中描述的各种因素对其热响应特性的影响。含有热响应链的 HEMA 聚集的研究涉及加热时形成的纳米颗粒的形态和尺寸。使用现有数据，我们试图揭示热响应链中 HEMA 含量对共聚物热性能的影响。HEMA 羟基的修饰导致了具有各种结构和拓扑结构的热响应大分子。通过改性引入的新功能改善了聚合物及其聚集体的特性（稳定性、生物相容性等）。基于 HEMA 的共聚物的热聚合允许创建生物活性物质的载体，我们在评论的单独部分中进行了介绍。评论中讨论的工作显示了使用 HEMA 获得用于医疗应用的热响应聚合物材料的重大可能性。基于 HEMA 的共聚物的热聚合允许创建生物活性物质的载体，我们在评论的单独部分中进行了介绍。评论中讨论的工作显示了使用 HEMA 获得用于医疗应用的热响应聚合物材料的重大可能性。基于 HEMA 的共聚物的热聚合允许创建生物活性物质的载体，我们在评论的单独部分中进行了介绍。评论中讨论的工作显示了使用 HEMA 获得用于医疗应用的热响应聚合物材料的重大可能性。