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The cancer therapy materialization by theranostic nanoparticles based on gold doped iron oxide under electromagnetic field amplification
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 5.4 ) Pub Date : 2021-04-29 , DOI: 10.1016/j.nano.2021.102406
Mohsen Shariati 1
Affiliation  

The harnessing of the cancer X-ray radiation therapy by gold-decorated Fe3O4 theranostic nanoparticles (Au-Fe3O4 NPs) under electromagnetic field was articulated. The applied electromagnetic field could assemble the NPs inside cell in oriented field direction and enhance the local irradiation dose inside cell. By materializing NPs, the absorption of the energy exposed by X-ray radiation under electromagnetic field was restricted. The cytotoxic properties of the Au-Fe3O4 NPs were assessed using MTT assay in L929, HeLa and PC3 cell lines under radiation and dark conditions. The efficiency of the Au-Fe3O4 NPs under 2 Gy dose radiations was higher than 6 Gy radiations in untreated cells. The in vitro measurements showed that under electromagnetic field and X-ray radiation therapy with Au-Fe3O4 NPs, around 90% of the cancer cells population was annihilated. The in vivo measurements indicated that the tumor shape and size under X-ray with Au-Fe3O4 NPs after 3 weeks were efficiently deteriorated.



中文翻译:

基于金掺杂氧化铁的治疗诊断纳米粒子在电磁场放大下的癌症治疗物化

阐述了在电磁场下通过金装饰的 Fe 3 O 4治疗诊断纳米粒子 (Au-Fe 3 O 4 NPs)对癌症 X 射线放射治疗的利用。施加的电磁场可以在定向场方向上组装细胞内的纳米颗粒,并提高细胞内的局部辐照剂量。通过使纳米颗粒物化,限制了电磁场下 X 射线辐射所暴露的能量的吸收。在辐射和黑暗条件下,在L929HeLaPC3细胞系中使用 MTT 测定法评估了 Au-Fe 3 O 4 NPs的细胞毒性。金铁的效率在未处理的细胞中,2 Gy 剂量辐射下的3 O 4 NPs 高于 6 Gy 辐射。体外测量表明,在使用Au-Fe 3 O 4 NPs的电磁场和X射线放射治疗下,大约90%的癌细胞群被消灭。体内测量表明,3周后在X射线下使用Au-Fe 3 O 4 NPs的肿瘤形状和大小得到有效恶化。

更新日期:2021-05-19
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