Pharmaceutical consumption is increasing worldwide as it is essential to treat and prevent health issues but they end up in the environment. However, in many African countries like Ethiopia, the status of these compounds in various environmental samples is not very well known. In this study, a simple method for the extraction and determination of thirteen pharmaceutical compounds of different therapeutic classes in water samples using solid-phase extraction and HPLC-DAD was developed. Different parameters affecting extraction were optimised and obtained as hydrophilic-lipophilic balance (HLB) extraction cartridge, water sample pH of 5, elution solvent of 2% formic acid in water with methanol (20:80%, v/v), a sample volume of 150 mL and addition of 0.5% w/v EDTA in the sample. The limits of detection and quantification of the optimised method were in the range of 0.1–0.8 µg/L and 0.2–2.6 µg/L, respectively. The relative recovery in the spiked environmental water sample was in the range of 70–117% except for amoxicillin and acetylsalicylic acid in influent wastewater. The precision for all ranged from 0.3 to 11%. The proposed method was successfully tested for the detection and quantification of different environmental water samples collected from Addis Ababa, Ethiopia. Trimethoprim, caffeine and albendazole concentrations of 7.8 (1.1), 3.2 (0.4) and 2.1 (0.1) µg/L were quantified in hospital wastewater, respectively. The concentration of norfloxacin was found to be below the limit of quantification in the same water. Trimethoprim and ciprofloxacin were also found in the sewage treatment plant influent sample at a concentration of 0.5 (0.02) and 0.3 (0.01) µg/L, respectively.

在世界范围内，由于治疗和预防健康问题必不可少的药品消费量正在增加，但它们最终会进入环境。但是，在埃塞俄比亚等许多非洲国家，这些化合物在各种环境样品中的状态还不是很清楚。在这项研究中，开发了一种使用固相萃取和HPLC-DAD萃取和测定水样品中13种不同治疗类别的药物化合物的简单方法。优化了影响萃取的不同参数，并获得了亲水-亲脂天平（HLB）萃取柱，水样品的pH值为5，洗脱液中2％甲酸的甲醇溶液（20：80％，v / v），样品体积150 mL并添加0.5％w /v样品中的EDTA。优化方法的检出限和定量限分别在0.1–0.8 µg / L和0.2–2.6 µg / L的范围内。加标的环境水样品中的相对回收率在70–117％的范围内，除了阿莫西林和进水废水中的乙酰水杨酸。所有的精度范围从0.3％到11％。所提出的方法已成功测试，用于检测和量化从埃塞俄比亚亚的斯亚贝巴收集的不同环境水样。医院废水中甲氧苄啶，咖啡因和阿苯达唑的浓度分别为7.8（1.1），3.2（0.4）和2.1（0.1）µg / L。发现诺氟沙星的浓度低于同一水中的定量极限。