Abstract

Hyaluronic acid (HA), an important component of the extracellular matrix, has high water solubility and biocompatibility, and good application prospects in biomedicine. Especially in tumour treatment, prodrug polymer micelles prepared from HA and chemotherapeutics can increase water solubility, prolong drug release time, improve organ distribution and therapeutic effects, and show good tumour targeting and biocompatibility. Therefore, this study introduces strategies for using HA to prepare prodrug polymer micelles and discusses recent research on HA prodrug micelles for antitumor applications.

中文翻译：

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用于肿瘤治疗的透明质酸前药胶束

摘要

透明质酸（HA）是细胞外基质的重要组成部分，具有较高的水溶性和生物相容性，在生物医学中具有良好的应用前景。尤其是在肿瘤治疗中，由HA和化疗药物制备的前药聚合物胶束可以增加水溶性，延长药物释放时间，改善器官分布和治疗效果，表现出良好的肿瘤靶向性和生物相容性。因此，本研究介绍了使用 HA 制备前药聚合物胶束的策略，并讨论了最近关于 HA 前药胶束用于抗肿瘤应用的研究。