Objective

To investigate the combinatorial effect of hydroalcoholic extracts of Andrographis paniculata Nees. and Pterocarpus marsupium Roxb. plants prospective to diabetes management.

Methods

Taking a lead from the scientific literature, in silico studies have also been designed for the screening of anti-diabetic targets against andrographolide and pterostilbene compounds followed by in vivo studies from Andrographis paniculata Nees. and Pterocarpus marsupium Roxb. Furthermore, the diabetes was induced by STZ model and the impact of Andrographis paniculata Nees. and Pterocarpus marsupium Roxb. have been conformed by relative expression studies by qPCR.

Results

Our results have shown that andrographolide and pterostilbene are SGLT2 inhibitors and selective PPARγ agonists in in silico studies. Later, during in vivo mRNA expression studies confirming the same pattern. The findings of the study has shown to overcome the common knowledge of the only C–glycoside based molecules inhibiting the SGLT2.

Conclusions

The possible mechanism for Ptyrone^TM in the management of diabetes could be a selective PPARγ agonist, GLUT4 translocation and SGLT2 inhibition molecule.

中文翻译：

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对Ptyrone ^TM的机械理解：基于植物的天然抗糖尿病产品

客观的

为了研究穿心莲穿心莲的水醇提取物的组合作用。和罗汉松（Pterocarpus marsupium Roxb）。有望用于糖尿病治疗的植物。

方法

在科学文献的指导下，还设计了计算机模拟研究来筛选针对穿心莲内酯和翼龙类化合物的抗糖尿病靶标，然后进行穿心莲穿心莲的体内研究。和罗汉松（Pterocarpus marsupium Roxb）。此外，糖尿病是由STZ模型和穿心莲的影响所致。和罗汉松（Pterocarpus marsupium Roxb）。已经通过qPCR的相对表达研究得到证实。

结果

我们的研究结果表明，在计算机研究中，穿心莲内酯和蝶呤二苯醚是SGLT2抑制剂和选择性PPARγ激动剂。后来，在体内mRNA表达研究期间，证实了相同的模式。该研究的结果表明克服了仅有的抑制SGLT2的基于C-糖苷的分子的常识。

结论

Ptyrone ^TM在糖尿病治疗中的可能机制可能是选择性的PPARγ激动剂，GLUT4易位和SGLT2抑制分子。