ABSTRACT

Introduction

Patients with irritable bowel syndrome (IBS) frequently resort to natural products, or request doctors to prescribe them, to relieve their symptoms, due to the poor efficacy and tolerability of several traditional drugs. Products containing fiber are among the most used and their clinical efficacy is discussed here based on the most recent scientific evidence.

Areas covered

A literature search was carried out to identify the most significant publications in order to deal with the topics of the general characteristics of fibers and the scientific evidence underlying their therapeutic use, the properties of ispaghula husk and the mechanisms by which this product carries out its therapeutic actions.

Expert opinion

The most recent clinical guidelines on the management of IBS consider ispaghula husk, a product containing soluble fiber, as a reasonable first line therapy for IBS patients with symptoms. In contrast, products containing insoluble fibers, particularly wheat bran, do not appear to be useful in treating IBS symptoms. The clinical data on the use of prebiotics in IBS are still inconclusive. However, low daily amounts of fructo-oligosaccharides or β-galacto-oligosaccharides (also known as trans-galacto-oligosaccharides) may be effective in improving IBS symptoms; further trials are needed to definitively establish their clinical usefulness.

中文翻译：

---

目前关于纤维治疗肠易激综合征的证据

摘要

介绍

由于几种传统药物的疗效和耐受性较差，肠易激综合征 (IBS) 患者经常求助于天然产品，或要求医生开处方以缓解症状。含有纤维的产品是最常用的产品之一，本文根据最新的科学证据讨论了它们的临床疗效。

涵盖的领域

进行了文献检索以确定最重要的出版物，以处理纤维的一般特征及其治疗用途的科学证据、ispaghula husk 的特性和该产品进行治疗的机制等主题行动。

专家意见

关于 IBS 管理的最新临床指南认为 ispaghula husk 是一种含有可溶性纤维的产品，作为有症状的 IBS 患者的合理一线治疗。相反，含有不溶性纤维的产品，特别是麦麸，似乎对治疗 IBS 症状没有用处。关于在 IBS 中使用益生元的临床数据尚无定论。然而，每日少量的低聚果糖或 β-低聚半乳糖（也称为反式低聚半乳糖）可能对改善 IBS 症状有效；需要进一步的试验来确定它们的临床实用性。