当前位置: X-MOL 学术Eur. J. Clin. Microbiol. Infect. Dis. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Characteristics and outcome of varicella-zoster virus central nervous system infections in adults
European Journal of Clinical Microbiology & Infectious Diseases ( IF 3.7 ) Pub Date : 2021-04-28 , DOI: 10.1007/s10096-021-04245-y
A Le Bot 1 , A Ballerie 2 , C Pronier 3 , F Bénézit 1 , F Reizine 1 , M Tas 4 , P Jégo 2 , M Revest 1 , Y Le Tulzo 1 , P Fillâtre 5 , Pierre Tattevin 1
Affiliation  

We conducted an observational retrospective study of all adults hospitalized for documented varicella-zoster virus (VZV) meningitis or encephalitis during years 2000–2015 in one referral centre. Thirty-six patients (21 males, 15 females) were included, with meningitis (n = 21), or meningoencephalitis (n = 15). Median age was 51 years [interquartile range, 35–76], and 6 patients (17%) were immunocompromised. Aciclovir was started in 32 patients (89%), with a median dose of 11 mg/kg/8 h [10–15]. No patient died, but 12 (33%) had neurological sequelae at discharge. Age was the only variable associated with adverse outcome (OR 1.98 [1.17–3.35] per 10-year increment, P = 0.011).



中文翻译:

成人水痘-带状疱疹病毒中枢神经系统感染特征及转归

我们对 2000 年至 2015 年期间在一个转诊中心因记录在案的水痘-带状疱疹病毒 (VZV) 脑膜炎或脑炎住院的所有成年人进行了一项观察性回顾性研究。包括 36 名患者(21 名男性,15 名女性),患有脑膜炎 ( n = 21) 或脑膜脑炎 ( n = 15)。中位年龄为 51 岁 [四分位距,35-76],6 名患者 (17%) 免疫功能低下。32 名患者 (89%) 开始使用阿昔洛韦,中位剂量为 11 mg/kg/8 小时 [10–15]。没有患者死亡,但 12 (33%) 名患者在出院时有神经系统后遗症。年龄是与不良结果相关的唯一变量(OR 1.98 [1.17–3.35] 每 10 年递增,P = 0.011)。

更新日期:2021-04-29
down
wechat
bug