The metastatic cancer disease represents the real and urgent clinical need in oncology. Therefore, an understanding of the complex molecular mechanisms sustaining the metastatic cascade is critical to advance cancer therapies. Recent studies highlight how redox signaling influences the behavior of metastatic cancer cells, contributes to their travel in bloodstream from the primary tumor to the distant organs and conditions the progression of the micrometastases or their dormant state. Radical oxygen species not only regulate intracellular processes but participate to paracrine circuits by diffusion to nearby cells, thus assuming unpredicted roles in the communication between metastatic cancer cells, blood circulating cells, and stroma cells at site of colonization. Here, we review recent insights in the role of radical oxygen species in the metastasis formation with a special focus on extravasation at metastatic sites.

转移性癌症代表了肿瘤学中真实而紧迫的临床需求。因此，了解维持转移级联的复杂分子机制对于推进癌症治疗至关重要。最近的研究强调了氧化还原信号如何影响转移性癌细胞的行为，有助于它们在血流中从原发肿瘤到远处器官，并调节微转移的进展或其休眠状态。自由基氧不仅调节细胞内过程，而且通过扩散到附近细胞参与旁分泌回路，从而在定植部位的转移性癌细胞、血液循环细胞和基质细胞之间的通讯中发挥不可预测的作用。在这里，我们回顾了自由基氧在转移形成中的作用的最新见解，特别关注转移部位的外渗。