当前位置：
X-MOL 学术
›
Ann. Indian Acad. Neurol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
The impact of COVID-19 pandemic on disease severity and quality of life in parkinson's disease
Annals of Indian Academy of Neurology ( IF 1.9 ) Pub Date : 2021-03-01 , DOI: 10.4103/aian.aian_1240_20 Alvee Saluja 1 , Jasmine Parihar 1 , Divyani Garg 1 , Rajinder K Dhamija 1
Background: The challenges being faced during the lockdown period may worsen motor or non-motor symptoms in Parkinson's disease (PD). Objective: This study was undertaken to investigate the impact of lockdown on the disease activity, caregiver perceptions and the quality of life of patients with PD. Materials and Methods: This cross-sectional study was conducted from June till September 2020. Sixty-four patients with PD and caregivers were interviewed telephonically after obtaining consent. The responses were recorded by means of a structured questionnaire. Non-motor symptoms scale (NMSS) and the Parkinson Disease Questinnaire-8 (PDQ-8) were applied. PDQ-8 severity index (PDQ-8 SI) scores were expressed as percentage of the raw PDQ-8 score of the total score. Data were analsyed by using SPSS version 20.0. Results: Of 64 patients, 39 (60.9%) were men and 25 (39.1%) were women. The overall median age of the patients was 65 (55.25–69.75) years. The median duration was 48 (30–84) months. Twenty-six (40.6%) patients reported symptomatic worsening during the lockdown period. Slowness in activities of daily living and walking worsened in 15 (57.7%) and 14 (53.8%) patients, respectively, while tremors increased in 12 (46.2%) patients. Mood and sleep disturbances were the most common non-motor symptoms to worsen. Increase in non-motor symptoms and the NMSS total score were independent predictors of PDQ-8 scores. Increase in non-motor symptoms during the lockdown was an independent predictor of the highest quartile of PDQ-8 SI scores. Conclusions: Motor and non-motor symptoms have worsened in patients with PD during the lockdown. The increase in non-motor symptoms was independently associated with poorer quality of life among patients with PD during the lockdown.
中文翻译：
COVID-19 大流行对帕金森病患者疾病严重程度和生活质量的影响
背景：封锁期间面临的挑战可能会加重帕金森病 (PD) 的运动或非运动症状。目的：本研究旨在调查封锁对 PD 患者疾病活动、护理人员的看法和生活质量的影响。材料和方法：这项横断面研究于 2020 年 6 月至 2020 年 9 月进行。64 名 PD 患者和护理人员在获得同意后接受了电话采访。回答通过结构化问卷进行记录。应用非运动症状量表 (NMSS) 和帕金森病问卷调查 - 8 (PDQ-8)。PDQ-8 严重性指数 (PDQ-8 SI) 分数表示为原始 PDQ-8 分数占总分的百分比。使用SPSS 20.0版对数据进行分析。结果：在 64 名患者中，39 名（60.9%）为男性，25 名（39.1%）为女性。患者的总体中位年龄为 65 岁（55.25-69.75）岁。中位持续时间为 48 (30-84) 个月。26 名 (40.6%) 患者报告在封锁期间症状恶化。15 名 (57.7%) 和 14 名 (53.8%) 患者的日常生活和行走活动缓慢恶化，而 12 名 (46.2%) 患者的震颤增加。情绪和睡眠障碍是最常见的恶化的非运动症状。非运动症状的增加和 NMSS 总分是 PDQ-8 评分的独立预测因子。锁定期间非运动症状的增加是 PDQ-8 SI 评分最高四分位数的独立预测因子。结论：在封锁期间，PD 患者的运动和非运动症状恶化。在封锁期间，非运动症状的增加与 PD 患者较差的生活质量独立相关。
更新日期：2021-04-29
Annals of Indian Academy of Neurology ( IF 1.9 ) Pub Date : 2021-03-01 , DOI: 10.4103/aian.aian_1240_20 Alvee Saluja 1 , Jasmine Parihar 1 , Divyani Garg 1 , Rajinder K Dhamija 1
Affiliation
Background: The challenges being faced during the lockdown period may worsen motor or non-motor symptoms in Parkinson's disease (PD). Objective: This study was undertaken to investigate the impact of lockdown on the disease activity, caregiver perceptions and the quality of life of patients with PD. Materials and Methods: This cross-sectional study was conducted from June till September 2020. Sixty-four patients with PD and caregivers were interviewed telephonically after obtaining consent. The responses were recorded by means of a structured questionnaire. Non-motor symptoms scale (NMSS) and the Parkinson Disease Questinnaire-8 (PDQ-8) were applied. PDQ-8 severity index (PDQ-8 SI) scores were expressed as percentage of the raw PDQ-8 score of the total score. Data were analsyed by using SPSS version 20.0. Results: Of 64 patients, 39 (60.9%) were men and 25 (39.1%) were women. The overall median age of the patients was 65 (55.25–69.75) years. The median duration was 48 (30–84) months. Twenty-six (40.6%) patients reported symptomatic worsening during the lockdown period. Slowness in activities of daily living and walking worsened in 15 (57.7%) and 14 (53.8%) patients, respectively, while tremors increased in 12 (46.2%) patients. Mood and sleep disturbances were the most common non-motor symptoms to worsen. Increase in non-motor symptoms and the NMSS total score were independent predictors of PDQ-8 scores. Increase in non-motor symptoms during the lockdown was an independent predictor of the highest quartile of PDQ-8 SI scores. Conclusions: Motor and non-motor symptoms have worsened in patients with PD during the lockdown. The increase in non-motor symptoms was independently associated with poorer quality of life among patients with PD during the lockdown.
中文翻译：
COVID-19 大流行对帕金森病患者疾病严重程度和生活质量的影响
背景：封锁期间面临的挑战可能会加重帕金森病 (PD) 的运动或非运动症状。目的：本研究旨在调查封锁对 PD 患者疾病活动、护理人员的看法和生活质量的影响。材料和方法：这项横断面研究于 2020 年 6 月至 2020 年 9 月进行。64 名 PD 患者和护理人员在获得同意后接受了电话采访。回答通过结构化问卷进行记录。应用非运动症状量表 (NMSS) 和帕金森病问卷调查 - 8 (PDQ-8)。PDQ-8 严重性指数 (PDQ-8 SI) 分数表示为原始 PDQ-8 分数占总分的百分比。使用SPSS 20.0版对数据进行分析。结果：在 64 名患者中，39 名（60.9%）为男性，25 名（39.1%）为女性。患者的总体中位年龄为 65 岁（55.25-69.75）岁。中位持续时间为 48 (30-84) 个月。26 名 (40.6%) 患者报告在封锁期间症状恶化。15 名 (57.7%) 和 14 名 (53.8%) 患者的日常生活和行走活动缓慢恶化，而 12 名 (46.2%) 患者的震颤增加。情绪和睡眠障碍是最常见的恶化的非运动症状。非运动症状的增加和 NMSS 总分是 PDQ-8 评分的独立预测因子。锁定期间非运动症状的增加是 PDQ-8 SI 评分最高四分位数的独立预测因子。结论：在封锁期间，PD 患者的运动和非运动症状恶化。在封锁期间，非运动症状的增加与 PD 患者较差的生活质量独立相关。
京公网安备 11010802027423号