Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. It is a chronic and progressive disorder estimated to affect at least 4 million people worldwide. Although the etiology of PD remains unclear, it has been found that the dysfunction of synaptic vesicle endocytosis (SVE) in neural terminal happens before the loss of dopaminergic neurons. Recently, accumulating evidence reveals that the PD-linked synaptic genes, including DNAJC6, SYNJ1 and SH3GL2, significantly contribute to the disruptions of SVE, which is vital for the pathogenesis of PD. In addition, the proteins encoded by other PD-associated genes such as SNCA, LRRK2, PRKN and DJ-1 also play key roles in the regulation of SVE. Here we present the facts about SVE-related genes and discussed their potential relevance to the pathogenesis of PD.

中文翻译：

---

帕金森氏病中突触囊泡内吞功能障碍

帕金森氏病（PD）是仅次于阿尔茨海默氏病的第二大最常见的神经退行性疾病。这是一种慢性和进行性疾病，估计全世界至少有400万人受到影响。尽管PD的病因尚不清楚，但是已经发现神经末梢的突触小泡内吞作用（SVE）功能障碍发生在多巴胺能神经元丧失之前。最近，越来越多的证据表明，PD连接的突触基因，包括DNAJC6，SYNJ1和SH3GL2，对SVE的破坏起了重要作用，这对PD的发病机理至关重要。此外，由其他与PD相关的基因（例如SNCA，LRRK2，PRKN和DJ-1）编码的蛋白质在SVE的调节中也起着关键作用。在这里，我们介绍了有关SVE相关基因的事实，并讨论了它们与PD发病机理的潜在相关性。