Background: For older patients with cancer, maintaining or regaining their ability to care of themselves is of major interest. Which tools are appropriate to measure this? Different tools to assess functional status (FS) are established in geriatric and oncological care, but they have been compared poorly in the past. Patients and Methods: Within a prospective cohort trial, we included 483 patients: 198 older patients with cancer, 156 younger patients with cancer, and 129 older patients with benign disease. FS was assessed as Eastern Cooperative Oncology Group performance status (ECOG-PS), activities of daily living (ADL), and instrumental activities of daily living (IADL). Results were compared for their differences in identifying patients as functionally compromised. Summary: The relative frequency of cancer patients with limitations in ECOG-PS, ADL, and IADL, respectively, increased from 25.7, 13.5, and 17.9% in those #x3c;60 years of age to 50.0, 47.1, and 66.7% in those ≥80 years. Results in older patients with cancer were comparable to older patients with benign disease. In older patients with cancer, 20.7 and 21.6% with a good ECOG-PS had limitations in ADL and IADL, respectively; of those without limitations in ADL and IADL, 34.7 and 26.0%, respectively, had a poor ECOG-PS. Treatment approach (curative vs. palliative) was found to be significantly associated with functional limitations. Key Messages: Geriatric and oncological measure of FS report differences in functional impairment. Geriatric functional measures are more sensitive to age-related changes and should be included as patient-reported outcomes in clinical trials and care.
Oncol Res Treat

中文翻译：

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对老年癌症患者进行详细的老年功能评估的重要性

背景：对于老年癌症患者，保持或恢复他们的自我照顾能力是主要的兴趣所在。哪些工具适合衡量这一点？在老年病学和肿瘤学护理中建立了不同的评估功能状态 (FS) 的工具，但过去对它们的比较效果不佳。患者和方法：在一项前瞻性队列试验中，我们纳入了 483 名患者：198 名老年癌症患者、156 名年轻癌症患者和 129 名老年良性疾病患者。FS 被评估为东部肿瘤合作组的体能状态 (ECOG-PS)、日常生活活动 (ADL) 和工具性日常生活活动 (IADL)。比较结果在将患者识别为功能受损方面的差异。概括：ECOG-PS、ADL 和 IADL 受限的癌症患者的相对频率分别从 #x3c;60 岁的 25.7、13.5 和 17.9% 增加到 ≥80 岁的 50.0、47.1 和 66.7%年。老年癌症患者的结果与老年良性疾病患者的结果相当。在老年癌症患者中，20.7% 和 21.6% 具有良好 ECOG-PS 的 ADL 和 IADL 分别存在局限性；在 ADL 和 IADL 没有限制的人中，分别有 34.7% 和 26.0% 的 ECOG-PS 较差。发现治疗方法（治愈性与姑息性）与功能限制显着相关。关键信息：FS 的老年学和肿瘤学测量报告了功能障碍的差异。老年功能测量对与年龄相关的变化更敏感，应作为患者报告的结果纳入临床试验和护理。
肿瘤资源治疗