Background: The effects of high-risk environment on young adults with mild asthma were never fully tested in practice, as most high-risk occupations do not welcome them. This study examines the effect of combat training on asthma worsening in the Israeli Defense Forces. Methods: Persons with asthma in remission and mild intermittent asthma who underwent combat training between 2014 and 2017 were compared in terms of disease worsening to their counterparts performing clerical duties during a follow-up of 8 months. Among combat trainees, exposure to known triggers for asthma exacerbation and health status on enlistment were assessed as risk factors for asthma exacerbation. Results: Asthma worsening among persons with asthma in remission was twice as common among those who are undergoing training compared to persons performing clerical duties. This difference was smaller among mild intermittent asthmatics. For both asthma severities, rates of asthma exacerbation requiring emergency room treatment were several times higher among the training group. Among individuals undergoing training, mild intermittent asthma was a significant risk factor for asthma worsening compared to asthma in remission (OR 1.99 [1.44–2.75]) while age (OR 0.67 [0.53–0.85]) and immigration to Israel (OR 0.55 [0.31–0.95]) were significant protective factors. Interpretation: Young adults with mild asthma are at significant risk for severe exacerbations when exposed to high-risk environment even among individuals who have long been symptom free. No single risk factor was found to have an independent effect suggesting a synergistic mechanism that is harder to mitigate.
Int Arch Allergy Immunol

中文翻译：

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从事高危职业的轻度哮喘青年：哮喘发作的发生率和危险因素

背景：高风险环境对患有轻度哮喘的年轻人的影响从未在实践中得到充分测试，因为大多数高风险职业不欢迎他们。本研究考察了战斗训练对以色列国防军哮喘恶化的影响。方法：在 8 个月的随访期间，将 2014 年至 2017 年间接受战斗训练的哮喘缓解期和轻度间歇性哮喘患者的病情恶化情况与执行文书工作的同行进行比较。在战斗学员中，暴露于已知的哮喘恶化诱因和入伍时的健康状况被评估为哮喘恶化的危险因素。结果：与从事文书工作的人相比，在接受培训的人中，哮喘缓解期患者的哮喘恶化率是其两倍。这种差异在轻度间歇性哮喘患者中较小。对于两种哮喘严重程度，训练组中需要急诊室治疗的哮喘恶化率要高出数倍。在接受训练的个体中，与缓解期（OR 1.99 [1.44-2.75]）和年龄（OR 0.67 [0.53-0.85]）和移民以色列（OR 0.55 [0.31]）相比，轻度间歇性哮喘是哮喘恶化的重要危险因素。 –0.95]) 是重要的保护因素。解释：患有轻度哮喘的年轻人在暴露于高风险环境时，即使在长期没有症状的个体中，也有发生严重哮喘发作的显着风险。没有发现单个风险因素具有独立效应，表明存在更难缓解的协同机制。
Int Arch 过敏免疫