The mutational landscape of colorectal cancer (CRC) does not enable predictions to be made about the survival of patients or their response to therapy. Instead, studying the polarization and activation profiles of immune cells and stromal cells in the tumour microenvironment has been shown to be more informative, thus making CRC a prototypical example of the importance of an inflammatory microenvironment for tumorigenesis. Here, we review our current understanding of how colon cancer cells interact with their microenvironment, comprised of immune cells, stromal cells and the intestinal microbiome, to suppress or escape immune responses and how inflammatory processes shape the immune pathogenesis of CRC.

结直肠癌 (CRC) 的突变情况无法预测患者的生存或他们对治疗的反应。相反，研究肿瘤微环境中免疫细胞和基质细胞的极化和激活特征已被证明可以提供更多信息，从而使 CRC 成为炎症微环境对肿瘤发生重要性的典型例子。在这里，我们回顾了我们目前对结肠癌细胞如何与其微环境（包括免疫细胞、基质细胞和肠道微生物组）相互作用以抑制或逃避免疫反应以及炎症过程如何影响 CRC 的免疫发病机制的理解。