Production of no carrier-added (NCA) 199 Au through nat Pt( n , γ ) reaction and subsequent purification using liquid-liquid extraction from other radioisotopes is studied in the context of theranostic application. Comparative separation of NCA 199 Au after dissolution of activated Pt target using three Cyanex compounds (Cyanex-272, Cyanex-302 and Cyanex-923) is evaluated. The extraction process is optimized in terms of the type of extractant, the concentration of extractant, extraction time and aqueous media (HNO 3 , NH 4 OH). Among these extractants, the Cynaex-923 is efficient and promising for rapid separation and production of NCA 199 Au from HNO 3 by high extraction %. Selective extraction of 199 Au from other Pt and Ir radioisotopes is observed. High recovery of 199 Au was obtained in the case of Cyanex-923 using 0.05 M thiourea dissolved in HCl or 2 M NaOH. Our results find the Cyanex-923 as a promising extractant for efficient separation of 199 Au from irradiated Pt target with high yield (99%).

中文翻译：

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反应器生产的199Au的痕量高效萃取方法足以满足核医学应用

在分子诊断学应用的背景下，研究了通过nat Pt（n，γ）反应生产无载体的（NCA）199 Au的方法，以及随后使用液-液萃取法从其他放射性同位素中提纯的方法。使用三种Cyanex化合物（Cyanex-272，Cyanex-302和Cyanex-923）溶解活化的Pt靶后，比较了NCA 199 Au的相对分离度。根据萃取剂的类型，萃取剂的浓度，萃取时间和水性介质（HNO 3，NH 4 OH）对萃取过程进行了优化。在这些萃取剂中，Cynaex-923是高效的，并有望以高萃取率从HNO 3中快速分离和生产NCA 199 Au。观察到从其他Pt和Ir放射性同位素中选择性提取199 Au。在Cyanex-923的情况下，使用0可获得199 Au的高回收率。将05 M硫脲溶​​解在HCl或2 M NaOH中。我们的结果发现，Cyanex-923是一种有前途的萃取剂，可以高效率（99％）从辐照的Pt靶中有效分离出199 Au。