This study displays the facile and fluent electrochemical determination of uric acid (UA) through exceptional copper oxide nanostructures (CuO), as an effective sensing probe. The copper oxide nanostructures were fabricated via an aqueous chemical growth method using sodium hydroxide as a reducing agent, which massively hold hydroxide source. Copper oxide nanostructures showed astonishing electrocatalytic behavior in the detection of UA. Different characterization techniques such as XRD, FESEM, and EDS were exploited to determine crystalline nature, morphologies, and elemental composition of synthesized nanostructures. The cyclic voltammetry (CV) was subjected to investigate the electrochemical performance of UA using copper oxide nanostructures modified glassy carbon electrode CuO/GCE. The CV parameters were optimized at a scan rate of 50 mV/s with −0.7 to 0.9 potential range, and the UA response was investigated at 0.4 mV. PBS buffer of pH 7.4 was exploited as a supporting electrolyte. The linear dynamic range for UA was 0.001–351 mM with a very low limit of detection observed as 0.6 µM. The proposed sensor was successfully applied in urine samples for the detection of UA with improved sensitivity and selectivity.

中文翻译：

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改进的CuO纳米结构放大的非酶电化学传感器，用于尿酸的灵敏测定

这项研究显示了通过特殊的氧化铜纳米结构（CuO）简便，流畅地电化学测定尿酸（UA），作为有效的传感探针。通过使用氢氧化钠作为还原剂的水化学生长方法来制造氧化铜纳米结构，所述氢氧化钠可大量容纳氢氧化物源。氧化铜纳米结构在UA的检测中显示出惊人的电催化行为。利用诸如XRD，FESEM和EDS等不同的表征技术来确定合成纳米结构的晶体性质，形态和元素组成。采用循环伏安法（CV）研究了使用氧化铜纳米结构修饰的玻碳电极CuO / GCE的UA的电化学性能。CV参数在-0.7至0.9电位范围内以50 mV / s的扫描速率进行了优化，并在0.4 mV下研究了UA响应。pH 7.4的PBS缓冲液被用作支持电解质。UA的线性动态范围为0.001-351 mM，检测极限很低，为0.6 µM。所提出的传感器已成功应用于尿液样品中，用于尿酸的检测，具有更高的灵敏度和选择性。