Depression and anxiety are highly comorbid constructs. However little is known about the mechanisms that underpin this comorbidity/connectivity or the divergence between constructs that seems to occur in adolescence. The current study targeted emotion regulation (ER) as a potential plausible mechanism for explaining how anxiety and depression symptoms in adolescence might begin to connect, perpetuate, and ultimately diverge from one another. Using data from a cross-sectional school-based study, of adolescent females (age 11–18 years; N = 615; majority were white (97.7%)), we modelled variation in ER using latent profile analysis. Then, using network analysis (NA), we generated separate depression-anxiety symptom networks for adolescents at varying levels of ER. Three latent classes of ER were identified (low ER 15%, intermediate ER 34%, high ER 51%). The results of the network comparison test found no significant differences in global strength between the ‘low ER’ and the ‘intermediate ER’ ability network. This study is among the first to attempt to model change in depression-anxiety symptom connectivity in adolescence in relation to a common contextual/risk factor. The current study therefore offers a unique contribution to the examination of the role of transdiagnostic factors in the study of adolescent depression and anxiety from a network perspective, and provides a promising framework for the study of ER among anxiety and depression symptomatology in adolescence.

抑郁和焦虑是高度共病的结构。然而，对于这种合并症/连接性或似乎在青春期发生的构建体之间差异的基础机制知之甚少。当前的研究将情绪调节（ER）作为一种可能的机制来解释青春期的焦虑和抑郁症状可能如何开始相互联系，永存并最终彼此分离。使用横断面校本研究的青少年女性（11-18岁；N = 615; 大部分是白人（97.7％）），我们使用潜在特征分析对ER的变化进行了建模。然后，使用网络分析（NA），我们为处于不同ER水平的青少年生成了单独的抑郁-焦虑症状网络。确定了三种潜在的ER类型（低ER 15％，中ER 34％，高ER 51％）。网络比较测试的结果发现，“低ER”能力网络和“中级ER”能力网络之间的整体强度没有显着差异。这项研究是首次尝试对与常见的情境/风险因素相关的青春期抑郁症-焦虑症状连通性变化进行建模的研究。因此，当前的研究从网络的角度为研究转诊因素在青少年抑郁症和焦虑症研究中的作用做出了独特贡献，