Abstract

The work describes a polydopamine-wrapped zeolitic imidazolate framework-8 (ZIF-8) coating constructed on the sulfonated polyetheretherketone (PEEK). The coating is not only conducive to the controllable Zn²⁺ releases, but also exhibits excellent photothermal capacity under near-infrared (NIR) irradiation. in vitro antibacterial experiments indicate the coating possesses bactericidal efficiencies of 100% against Staphylococcus aureus and Escherichia coli under NIR. Without NIR, the ZIF-8/pDA-functionalized substrate shows favorable biocompatibility and enhanced osteogenic activities. We are convinced that this study may provide prospective opinions for developing the PEEK implants with photoinduced disinfection and osteogenesis for the repair of infected bone defects.

摘要

该工作描述了在磺化聚醚醚酮 (PEEK) 上构建的聚多巴胺包裹的沸石咪唑酯骨架 8 (ZIF-8) 涂层。该涂层不仅有利于Zn ²⁺的可控释放，而且在近红外（NIR）照射下表现出优异的光热容量。体外抗菌实验表明该涂层对金黄色葡萄球菌和大肠杆菌的杀菌效率为100%近红外下。在没有 NIR 的情况下，ZIF-8/pDA 功能化底物显示出良好的生物相容性和增强的成骨活性。我们相信，这项研究可能为开发具有光诱导消毒和成骨功能的 PEEK 植入物用于修复感染的骨缺损提供前瞻性意见。