Altered tissue mechanics and metabolism are defining characteristics of cancer that impact not only proliferation but also migration. While migrating through a mechanically and spatially heterogeneous microenvironment, changes in metabolism allow cells to dynamically tune energy generation and bioenergetics in response to fluctuating energy needs. Physical cues from the extracellular matrix influence mechanosignaling pathways, cell mechanics, and cytoskeletal architecture to alter presentation and function of metabolic enzymes. In cancer, altered mechanosensing and metabolic reprogramming supports metabolic plasticity and high energy production while cells migrate and metastasize. Here, we discuss the role of mechanoresponsive metabolism in regulating cell migration and supporting metastasis as well as the potential of therapeutically targeting cancer metabolism to block motility and potentially metastasis.

改变的组织力学和新陈代谢是癌症的定义特征，不仅影响增殖而且影响迁移。在通过机械和空间异质微环境迁移时，新陈代谢的变化使细胞能够动态调整能量产生和生物能量学，以响应波动的能量需求。来自细胞外基质的物理信号会影响机械信号通路、细胞力学和细胞骨架结构，从而改变代谢酶的呈现和功能。在癌症中，改变的机械传感和代谢重编程支持代谢可塑性和高能量产生，同时细胞迁移和转移。这里，