To establish the optimal detection of third-generation cephalosporin-resistant Enterobacterales (3GCREB), the performance of four different screening methods has been investigated: stool samples without (A) and with (B) pre-enrichment and rectal swabs without (C) and with (D) pre-enrichment were contrasted. Pre-enrichment approaches (B and D) increased the detection of 3GCREB carriers by 29.4% (20/68 3GCREB carriers only found using pre-enrichment, p < 0.0001) compared to direct plating approaches (A and C). Moreover, the study demonstrates a minor advantage of stool samples in contrast to rectal swabs in both cases (with and without pre-enrichment). Registration number: DRKS00022520, 24 July 2020.

为了建立对第三代耐头孢菌素肠杆菌 (3GCREB) 的最佳检测，我们研究了四种不同筛查方法的性能：没有 (A) 和 (B) 预富集的粪便样本和没有 (C) 的直肠拭子和与（D）预富集进行了对比。 与直接电镀方法（A 和 C）相比，预富集方法（B 和 D）将 3GCREB ​​载体的检测率提高了 29.4%（仅使用预富集发现的 20/68 3GCREB ​​载体，p < 0.0001）。此外，该研究表明，在两种情况下（有和没有预富集），粪便样本与直肠拭子相比具有较小的优势。注册号：DRKS00022520，2020 年 7 月 24 日。