Abstract

Aim: Chronic spontaneous urticaria (CSU) is characterised by itchy, red and raised lesions that appear as an attack without any cause and last for six weeks or longer. Omalizumab is a humanised monoclonal antibody that selectively binds to the Ce3 moiety of circulating IgE and is indicated for the treatment of resistant CSU. In this study, we aimed to investigate whether there was peripheral nervous system involvement in patients with chronic urticaria receiving omalizumab treatment.

Methods: Forty-seven patients who were treated with omalizumab for CSU were included in the study. Electrophysiological measurements were performed following a neurological examination before treatment and at three months after omalizumab treatment. In nerve conduction tests, eight different nerves were studied in four extremities (total 16 nerves). During these studies, two motor and two sensory nerves (median and ulnar) in the upper extremities, and two motor (tibial and common peroneal) and two sensory nerves (sural and superficial peroneal) in the lower extremities were analysed.

Results: No pathological electrophysiological findings supporting neuropathy were detected in any of the measurements performed before and after treatment. When the nerve conduction velocity, amplitude and latency values ​​of all examined nerves were compared, no significant difference was found between the pre- and post-treatment values.

Conclusions: It can be considered that omalizumab has no effect on peripheral nerves, and it is a safe and well tolerated agent in terms of both peripheral nerves and neurological structure.

摘要

目的：慢性自发性荨麻疹 (CSU) 的特征是发痒、发红和凸起的病变，表现为无任何原因的发作，持续六周或更长时间。奥马珠单抗是一种人源化单克隆抗体，可选择性结合循环 IgE 的 Ce3 部分，适用于治疗耐药性 CSU。在本研究中，我们旨在调查接受奥马珠单抗治疗的慢性荨麻疹患者是否存在外周神经系统受累。

方法：本研究纳入了 47 名接受奥马珠单抗治疗的 CSU 患者。在治疗前和奥马珠单抗治疗后三个月进行神经学检查后进行电生理测量。在神经传导测试中，研究了四肢的八种不同神经（总共 16 条神经）。在这些研究中，分析了上肢的两条运动神经和两条感觉神经（正中和尺神经），以及下肢的两条运动神经（胫骨和腓总神经）和两条感觉神经（腓骨和腓浅）。

结果：在治疗前后进行的任何测量中均未检测到支持神经病变的病理电生理结果。当比较所有受检神经的神经传导速度、幅度和潜伏期值时，未发现治疗前和治疗后值之间存在显着差异。

结论：可以认为奥马珠单抗对周围神经没有影响，无论是从周围神经还是神经结构来看，都是一种安全且耐受性好的药物。