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Placentas associated with female neonates from pregnancies complicated by urinary tract infections have higher cAMP content and cytokines expression than males
American Journal of Reproductive Immunology ( IF 2.5 ) Pub Date : 2021-04-27 , DOI: 10.1111/aji.13434
Andrea Olmos-Ortiz 1, 2 , Alberto Olivares-Huerta 1 , Janice García-Quiroz 1 , Teresa Zariñán 3 , Roberto Chavira 1 , Verónica Zaga-Clavellina 4 , Euclides Avila 1 , Ali Halhali 1 , Marta Durand 1 , Fernando Larrea 1 , Lorenza Díaz 1
Affiliation  

The cAMP pathway is involved in important biological processes including immune regulation and hormone signaling. At the feto-maternal unit, cAMP participates in placental function/physiology and the establishment of immunoendocrine networks. Low cAMP in male fetuses cord blood has been linked to poorer perinatal outcomes; however, cAMP placental content and its relationship with immune factors and fetal sex in an infectious condition have not been investigated.

中文翻译:

妊娠合并尿路感染的女性新生儿相关胎盘比男性具有更高的 cAMP 含量和细胞因子表达

cAMP 通路参与重要的生物学过程,包括免疫调节和激素信号传导。在胎儿-母体单位,cAMP 参与胎盘功能/生理学和免疫内分泌网络的建立。男性胎儿脐带血中的低 cAMP 与较差的围产期结局有关;然而,尚未研究 cAMP 胎盘含量及其与免疫因素和胎儿性别在感染情况下的关系。
更新日期:2021-04-27
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